摘要
本实验以成年新西兰兔为实验对象,观察透明质酸钠关节内注射预防骨关节炎的效果。以Hulth法建立膝关节骨关节炎模型,术毕及术后每隔1周关节内注射1%透明质酸钠1ml,分别于术后4周、8周、12周处死动物,作大体标本手术显微镜观察并取股骨内髁软骨标本进行光镜及透射电镜观察。结果显示实验组之骨关节炎改变较对照组明显减轻。这一结果提示外源性透明质酸钠能有效地减轻关节软骨的退变,降低关节手术后创伤性骨关节炎的发生率。
TwentyfouradultNewZealandrabbitswereusedasanimalmodelsforevaluatingtheefectofintraarticularsodiumhyaluronateinjectionforthepreventionofosteoarthritis(OA).Themod-elofOAofthekneewasestablishedwithHulthtechnique.ThenthemodelOAkneejointwasinjectedwith1ml1%sodiumhyaluronateattheendoftheoperationandtheneverytwoweekspostopratively.Theanimalsweresacrificedat4,8and12weekspostoperatively.Thearticularcartilagewasexaminedbysurgicalmicroscopyandthemedialfemoralcondylarwasexcisedandpreparedforthelightmicro-scopicandtransmissionelectronmicroscopicstudy.Therewasasignificantdelayandlesseningofthedegenerativechangesofarticularcartilageinexperimentalgroup.Thesefindingsindicatedthatexoge-noushyaluronatecanaleviatethedegenerationofarticularcartilagesandreducethemorbidityoftrau-maticosteoarthritis.
出处
《中华骨科杂志》
CAS
CSCD
北大核心
1996年第1期37-39,共3页
Chinese Journal of Orthopaedics
关键词
透明质酸钠
骨关节炎
预防
sodiumhyaluronateosteoarthritisprevention