摘要
目的综述国内外关于成骨细胞细胞外基质(extracellularmatrix,ECM)的研究进展,以及ECM在骨组织工程中的应用。方法广泛查阅近期相关文献,对骨组织工程中经常涉及的ECM进行分析。结果ECM的组成极其复杂,不仅决定细胞的形态,而且还控制细胞的黏附、迁移、增殖与分化。对于正在走向市场化的组织工程而言,ECM的水平反映了组织工程替代品的生物活性,有助于预测修复的效果。结论ECM有望成为检测组织工程产品的有效指标。
Objective To review the research progress of osteoblast extracellular matrix (ECM) and its application in bone tissue engineering. Methods The recent related literatures were extensively reviewed. Results The ECM was complex in its components. The configuration of cell and cell's adhésion, migration, proliferation, and differentiation were subject to the ECM. The bioactivity of the tissue engineering products was revealed by ECM, which predicted the product's efficiency in clinic application. Conclusion ECM has the potential to become the effective index in evaluating tissue engineered products.
出处
《中国修复重建外科杂志》
CAS
CSCD
北大核心
2006年第1期61-64,共4页
Chinese Journal of Reparative and Reconstructive Surgery
基金
国家高技术研究发展计划(863)资助项目(2001AA216011)
国家自然科学基金资助项目(39830100)
关键词
细胞外基质
成骨细胞
骨组织工程
研究进展
Extracellular matrix Osteoblast Bone tissue engineering Research progress