摘要
目的:制备盐酸莫西沙星凝胶并建立其质量控制方法。方法:以卡波姆934为基质制备凝胶,采用高效液相色谱法测定盐酸莫西沙星含量,并考察其稳定性。结果:盐酸莫西沙星进样量在0·4μg^3μg范围内与峰面积积分值线性关系良好(r=0·9999),平均回收率为98·41%(RSD=1·42%,n=6)。结论:本处方设计合理,稳定性好,质量控制方法准确、可靠。
OBJECTIVE. To prepare moxifloxacin hydrochloride gel and to establish a quality control method for the gel. METHODS： The gel was prepared with carbopol 934 as base, the content of moxifolxacin hydrochloride was determined by HPLC and the stability of which was investigated. RESULTS： The linear range of moxifloxacin hydrochloride was 0.4μg-3μg （r=0.9 999）, the average recovery was 98.41% （RSD = 1.42%, n = 6） . CONCLUSION： The gel is reasonable in performulation, satisfactory in stability, and accurate and reliable in quality control.
出处
《中国药房》
CAS
CSCD
北大核心
2005年第24期1873-1874,共2页
China Pharmacy
关键词
盐酸莫西沙星
凝胶
制备
质量控制
Moxifloxacin hydrochloride
Gel
Preparation
Quality control
