期刊文献+

HLA-DRB1基因与子痫前期相关性研究 被引量:5

Research on polymorphism of HLA-DRB1 in preeclampsia
原文传递
导出
摘要 目的探讨HLA-DRB1基因与子痫前期相关性。方法采用序列特异性引物技术(PCR-SSP)对119例子痫前期患者、117例正常孕妇及其新生儿进行HLA-DRB1等位基因分型,比较其基因频率。结果共检出13种等位基因,两组孕母或两组新生儿间,其HLA-DRB1等位基因频率差异无统计学意义(Pc>0.05);子痫前期组和正常晚孕组母婴所携带HLA-DRB1*04、-DRB1*10、-DRB1*14等位基因配伍差异有统计学意义(P<0.05)。结论母婴所携带某些HLA-DRB1基因配伍与子痫前期易感性或抗性相关;父源性HLA-DRB1*04基因与子痫前期易感性相关。 Objective To analyze the association between polymorphism of HIA-DRB1 genes and preeclampsia. Methods HL4-DRB1 genotyping was performed by polymerase chain reaction sequence-specific primer(PCR-SSP) in 119 preeclampsia patients, 117 normal pregnant women and their neonates. Results Thirteen alleles were obtained. There was not significant difference between preeclampsia group and control group ( Po 〉 0.05). The frequencies of HL4-DRB1 * 04, -DRB1* 10 and -DRB1 * 14 maternal/fetus special bindings were significantly different between preectampsia group and control group( P 〈 0.05). Conclusion Some HIA-DRB1 maternal/fetus special bindings may be associated with the susceptibility or protective of pre-eelampsia. Paternal HIA-DRB 1 * 04 may be a susceptible gene.
出处 《中华微生物学和免疫学杂志》 CAS CSCD 北大核心 2005年第12期979-983,共5页 Chinese Journal of Microbiology and Immunology
基金 河南省科技攻关项目(524410022)
关键词 人类白细胞抗原 子痫前期 等位基因 多态性 Human leucocyte antigen Preeclampsia Allele Polymorphism
  • 引文网络
  • 相关文献

参考文献10

  • 1Chaouat G,Ledee-bataile N,Zourbas S,et al.Implantation,can immunological parameters of implantation failure be of interest for preeclampsia.J Reprod Immunol,2003,59(2):205-217.
  • 2Bunce M,O'Neill CM,Barnardo MCNM,et al.Phototyping:comprehensive DNA typing for HLA-A,-B,-C,DRB1,DRB3,DRB4,DRB5 & DQB1 by PCR with 144 primer mixes utilizing sequence-specific primers (PCR-SSP).Tissue Antigens,1995,46(5):355-367.
  • 3Emery AEH.Methodology in medical genetics,2nd,LGL,1986:114-125.
  • 4Billingham RE,Brent L,Medawar PB.Activity acquired tolerance of foreign cells.Nature,1953,172(4379):603-606.
  • 5Hayward C,Livingstone J,Hollomay S,etal.An exclusion map for Preeclampsia:assuming autosomal recessive inheritance.Am J Hum Genet,1992,50(4):749-757.
  • 6吴乾渝,张振钧,范丽安,杨珏琴,蒋黎华,毛羽,姚芳娟.妊高征与人类白细胞抗原相关性的研究[J].中华妇产科杂志,1997,32(1):6-8. 被引量:17
  • 7Takakuwa K,Honda K,Ishii K,et al.Studies on the HLA DRB1 genotypes in Japancs women with severe Preeclampsia positive and negative for anti-cardiolipin antibody using a polymerase chain reaction restriction frag-ment length polymorphism method.Hum Reprot,1999,14(12),2980-2986.
  • 8Luppi P,McKnight C,Mathie T,et al.Evidence for superantigen involvement in preeclampsia.Am J Reprod Immunol.2000,43(4):187-196.
  • 9Carreiras M,Montagnani S,Layrisse Z.Preeclampsia:a multifactorial disease resulting from the interaction of the feto-maternal HLA genotype and HCMV infection.Am J Reprod Immunol.2002,48(3):176-183.
  • 10de Luca Brunori I,Battini L,Simonelli M,et al.HLA-DR in couples associated with preeclampsia:background and updating by DNA sequencing.J Reprod Immunol,2003,59(2):235-243.

二级参考文献1

  • 1郑怀美,妇产科学(第3版),1990年,110页

共引文献16

同被引文献70

引证文献5

;
使用帮助 返回顶部