持续性血糖监测系统临床应用的可靠性研究

Study on clinical utility of continuous glucose monitoring system

目的研究持续性血糖监测系统(CGMS)在临床中监测血糖的准确性和可靠性。方法以2003-10～2005-03第四军医大学附属西京医院48例2型糖尿病患者为研究对象,采用相关系数、绝对差值的均数、灵敏度和特异度等统计学方法比较CGMS血糖值与末稍指血血糖值之间的差异。结果患者佩戴CGMS的平均时间为(71.4±0.6)h,CGMS血糖值与指血血糖值相关系数波动于0.79～0.90之间,绝对差值的均数波动于6.7%～10.0%之间,CGMS监测高血糖的敏感度和特异度分别为93.15%和95.95%。结论CGMS监测的皮下组织葡萄糖浓度与末梢指血血糖浓度有良好的相关性,表明CGMS监测2型糖尿病患者血糖具有很好的临床实用性。

Objective To determine the accuracy and reliability of continuous glucose monitoring system （CGMS） in intensive monitoring blood glucose level. Methods The analysis was conducted on 48 type 2 diabetes patients to compare the glucose levels of glucose meter and CGMS. Each patients received CGMS for 3 days during his/her hospitalization. The data were analyzed according to correlation coefficient analysis, mean absolute error, sensitivity and specificity. Results The mean duration of CGMS recording was （71.4 ±0. 6） h. From the data that paired glucose readings and CGMS, the coefficients of correlation ranged from 0. 79 to 0. 90 and the mean absolute error ranged from 6. 7% to 10. 0%. The sensitivity and specificity to detect hyperglycemia were 93. 15% and 95.95% , respectively. Conclusion There is a good correlation between sensor readings of interstitial fluid glucose level and capillary blood glucose readings. The results indicate that CGMS is of clinical utility as a holter- type glucose tracking device.