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纳络酮可逆转急性心肌梗塞的压力反射钝化

Naloxone can reverse blunted baroreflex sensitivity after acute myocardial infarction
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摘要 以大鼠急性心肌梗塞(AMI)模型,观察静脉及小脑延髓池注射纳络酮(Nal)对AMI前及AMI后lhBRS的影响,发现,无论AMI前后静脉及小脑延髓池给予Nal均有加强BRS作用.这一结果提示:Nal可能有助于AMIBRS钝化的逆转. Acute myocardial infarction (AMI) model was made in SD rats by coronary ligation, the effects of naloxone (Nal) on the baroreflex sensitivity (BRS) were evaluated by administrated Nal intravenously (iv) and in-tracisternally (ic) before and after 1 h of AMI.Results showed that both pre and post AMI can Nal potentiate the BRS whether iv or ic. These results indicate that Nal may reverse the blunted BRS after AMI.
出处 《中国药理学通报》 CAS CSCD 北大核心 1996年第2期174-175,共2页 Chinese Pharmacological Bulletin
关键词 纳络酮 急性 心肌梗塞 压力反射敏感性 naloxone acute myocardial in-farction baroreflex sensitivity
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  • 1M. A. Petty,J. L. Reid. The effect of opiates on arterial baroreceptor reflex function in the rabbit[J] 1982,Naunyn - Schmiedeberg’s Archives of Pharmacology(3):206~211
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