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中晚期鼻咽癌后程加速超分割放疗的近期疗效观察 被引量:1

Preliminary report of late course accelerated hyperfractionated radiotherapy for advanced nasopharyngeal carcinoma
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摘要 目的:观察鼻咽癌后程加速超分割放射治疗(LCAF)的近期疗效和毒性反应。方法:60例鼻咽癌患者随机分为常规分割放射治疗(CF)组和LCAF组,CF组患者鼻咽部和颈部全程行常规分割放疗,LCAF组先常规放疗36 Gy,25 d,然后采用LCAF照射33~35 Gy,16~18 d,每日2次,间隔时间6 h,鼻咽部剂量为65~75Gy。有颈部淋巴结转移者颈部照射剂量68~74 Gy,无颈部淋巴结转移者预防照射剂量55~60 Gy。放射治疗结束时、放疗结束后3个月复查鼻咽部CT、纤维鼻咽镜、颈部CT和/或B超检查,综合评价放疗疗效。结果:放疗结束后 3个月LCAF组肿瘤全部消退率为79.31%,CF组为54.84%,差异有统计学意义(χ2=4.038 0,P<0.05),LCAF 组与CF组比较,Ⅰ、Ⅱ、Ⅲ度急性放射反应发生率差异无统计学意义(χ2=0.202 0,P>0.05)。结论:LCAF放射治疗可以改善中晚期鼻咽癌的局部控制率,而不增加急性放射反应。 Objective: To evaluate the immediate response and radio toxicity of lare course accelerated hyperfractionated radiotherapy for advanced nasopharyngeal carcinoma. Methed: From June 2001 to December 2002, 60 patients with advanced nasopharyngeal carcinoma were devided into conventional fraetionation (CF) and late course accelerated hyperfractionated radiotherapy (LCAF) groups. Thirty-one patients in CF group received conventional radiotherapy. Twenty night patients in LCAF group were treated with the same fractionation as CF group until the dose of 36Gy, and then followed by late course accelerated hyper-fractionated radiotherapy:1. 2-1.3 Gy/f, twice daily with 6-8 hour interval between the two fractions, to the total dose of 65-75Gy in 41 47days. Results: The complete response rate was 79.31% in the LCAF group and 54.84% in the CF group after 3 months of radiotherapy. The difference is significant between two groups, but without finding any significant difference in acute radio toxicity . Conclusion: LCAF radiotherapy can improve local control of nasopharyngeal carcinoma and does not increase the acute radio toxicity.
出处 《新疆医科大学学报》 CAS 2006年第1期62-64,共3页 Journal of Xinjiang Medical University
关键词 中晚期鼻咽癌 后程加速超分割放疗 近期局部疗效 advanced nasopharyngeal carcinoma late course accelerated hyperfractionated radiotherapy immediate response rate
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