摘要
目的探讨氯丙嗪和思瑞康对血清催乳素及子宫内膜的影响及意义。方法对52例女性初发精神分裂症患者在两种药物治疗前、治疗后2周、4周分别检测血清催乳素水平并作B超探测子宫内膜厚度,比较两组结果的差异。结果氯丙嗪组在用药后2周、4周血清催乳素水平逐渐升高且子宫内膜明显增厚,具有显著性差异(P<0.05);与思瑞康相比,疗后2周、4周分别也具有显著性差异(P<0.05)。结论非高度选择性D2受体的新型抗精神病药优于传统抗精神病药,具有良好的服药依从性。
Objective To investigate effects of chlorpromazine and serognel on the plasma levels of prolatin (PRL) and the endometrium thick. Methods Fifty-two patients with first-episode schizophrenia were tested plasma levels of PRL, and made B-ultrasonic wave for endometrium thick, before treatment and after 2, 4-week with two kinds of drugs respectively. Results There were significantly differences of plasma PRL and endometrium thick after 2, 4-week treatment between two groups (P〈0. 05) ; in chlorpromazine group, there were significant increase of plasma PRL after 2, 4-week treatment (P〈0. 05), no significant defference in serognel group (P〉0. 05). Conclusion Atypical antipsyehotics were superior to typical ones on compliance.
出处
《中国健康心理学杂志》
2006年第1期49-50,共2页
China Journal of Health Psychology
关键词
氯丙嗪
思瑞康
催乳素
子宫内膜
Chlorpromazine
Seroguel
Prolactin
Endometrium