广东食管癌高低发区烟酒消费与食管癌的关系

Correlations of alcohol and tobacco consumption with esophageal cancer in inhabitants from high and low-risk areas for esophageal cancer in Guangdong

目的研究南方食管癌高发区及低发区人群烟酒消费与食管癌的关系。方法在广东高发区南澳县、低发区汕尾市采用整群抽样方法调查608名居民的吸烟、饮酒习惯。采用构筑式logistic回归及协方差分析法研究烟酒消费与食管癌的联系。结果南澳男性居民吸烟率比汕尾高13.3%,但女性吸烟率两地相同。消除年龄影响后,南澳男性居民人均累计吸烟量比汕尾多4 582包;男性人均累计吸烟量每增加1 000包,发生高食管癌死亡率的估计危险性增加1.196倍。结论吸烟量可能在南澳男性居民食管癌病因学中起着一定作用。

Objective To explore the correlation between cigarette smoking, alcohol drinking and the mortality rate of esophageal cancer in the population from high and low-risk areas in Guangdong. Methods Total 608 healthy subjects from Nanao （the high-risk area） and Shanwei （the low-risk area） were selected by a random cluster sampling. Structured multiphase logistic regression and covariance analysis were performed. Results The smoking ratio of male inhabitants in Nanao was higher than that in Shanwei. The mortality rate of esophageal cancer in male may increase by 19.6 percent for every an increase of one thousand packages of accumulative smoking dose per capita. Conclusions Smoking dose may play a certain role in etiology of esophageal cancer in male inhabitants of Nanao.