河南食管癌高发区食管癌高癌家族调查

Epidemiological investigation on familial esophageal cancer from the subjects at high incidence area in Henan

目的:了解食管癌家族聚集性的流行状况。方法:采用统一问卷调查表,逐户调查。对河南省食管癌高发区448户1107人进行家系调查。结果:共收回264份问卷。264户中,有家族性食管癌共153户(58%)。直系三代中发生10例以上食管癌患者的家庭有5户(2%),7例患者的家庭有8户(3%),而三代中发生6例、5例、4例和3例食管癌的家庭分别为13户(5%)、21户(8%)、28户(11%)和46户(17%)。结论:河南食管癌高发区食管癌家族聚集性发生十分常见,提示遗传因素在食管癌变中可能起重要作用。

Aim ： To further understand the prevalence of familial esophageal cancer （EC） and to establish familial esophageal cancer model through the epidemiological investigation on the subjects at the high-incidence area in Henan. Methods： Standard questionnaires were distributed to 1 107 subjects from 448 households. Results： The investigation on 264 households demonstrated that, within continuous three generations, there were 5 households （2%） with more than 10 EC patients; 8 households with 7 EC patients （3%） ; and the number of households with 6, 5,4 and 3 EC patients was 13 （5%） , 21 （8%） , 28（ 11% ） and 46（ 17% ） , respectively. Of the 264 households interviewed, there were 153 households （58%） with familial esophageal cancer history. Conclusion： The prevalence for familial EC in the high-incidence area forEC in Henan is high, which suggests that genetic changes may play an important role in EC.