骨组织工程生物活性支架研究进展

Progress in research and application of bioactive scaffolds in bone tissue engineering

新型支架材料的研究趋势呈单一组分向多组分过渡,惰性材料向活性材料过渡,宏观水平向微观水平过渡。随着纳米技术与生命科学的迅猛发展,纳米改性与仿生构建这两个新理念也逐渐融入了支架研究的主流,网络成骨理论近年也在支架领域得到很好的拓展与应用。如何在原有研究的基础上研获理想的生物活性支架,已成为骨组织工程这一重大课题的核心热点和难点。本文重点探讨了骨组织工程中极具前景的几类生物支架,对其国内外研究与临床应用的现状做一综述。

The research on novel scaffold materials is now characterized by a transition from single element to composition, from inert materials to bioaetive materials, and from macro-level to micro-level. With the rapid development of nano-teehnology and life sciences, the two concepts of nano-modifieation and biomimie construction joined the mainstream of the scaffold research. And in this field, the theory of bone generation net has been recently explored systematically and comprehensively. As a result, it has now become a research focus to obtain ideal bioaetive scaffolds on the basis of current investigation. This paper highlights several types of promising scaffolds, discusses their recent research and application, and reviews the present situation concerning bioaetive scaffolds.