摘要
目的探讨基因重组和尿卵泡刺激素在体外受精(IVF)和卵胞浆内单精子注射(ICSI)的妊娠结局。方法在促性腺激素释放激素激动剂(GnRHa)长或短方案下,分别应用尿卵泡刺激素(uFSH)、高纯度尿卵泡刺激素(hpFSH)和基因重组卵泡刺激素(rFSH)促排卵,回顾性分析1049例实施IVF和ICSI的治疗周期。结果无论在GnRHa长或短方案中,uFSH组和hpFSH组ICSI的受精率较IVF显著降低(P<0.0001),但在rFSH组两者无明显差异;而且各组之间IVF和ICSI的种植率或妊娠率亦无统计学差异。结论在IVF和ICSI周期治疗中,uFSH、hpFSH与rFSH具有等同的胚胎种植率和临床妊娠率。
Objective To analyze IVF and ICSI outcome using recombinant and urinary FSH preparations. Methods Comparative analysis of 1049 patients undergoing IVF and ICSI cycles, who receiving urinary FSH （uFSH）, highly purified urinary FSH （hpFSH） or recombinant FSH （rFSH） in combination with different GnRH agonist （GnRHa） regimens. Results In the long and stop GnRHa protocols, the use of uFSH and hpFSH resulted in a lower fertilization rate in ICSI group （ P 〈0.0001）;no differences in fertilization rate were observed in the use of rFSH. There was no impact of the FSH preparation on implantation or pregnancy outcome when comparing IVF versus ICSI. Conclusion Recombinant FSH is at least as effective as urinary FSH preparations when used in IVF and ICSI options.
出处
《宁夏医学杂志》
CAS
2006年第2期83-85,共3页
Ningxia Medical Journal
基金
国家留学基金资助项目(No.21864017)
