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水通道蛋白与糖尿病肾病 被引量:6

Aquaporins and diabetic nephropathy
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摘要 水通道蛋白即存在于细胞膜上的特异性水转运孔道,目前发现的水通道蛋白已有11种。有研究证明,在糖尿病中水通道蛋白-1,2,3的表达是上调的,这有助于防止糖尿病时机体溶质和水的进一步丢失。有学者认为糖尿病肾病中尿排泄水通道蛋白-2减少,这可能与集合管细胞对血管加压素应答的细胞信号转导途径受损有关,而且在糖尿病酮症酸中毒患者治疗期间,可以通过尿排泄水通道蛋白-2来估计循环血容量的恢复情况。 The aquaporins (AQPs) belong to water-specific membrane channel proteins family, and eleven aquaporins have been identified up to date, Recent studies suggest that AQP-1, A QP-2 and AQP-3 wen up-regulated in diabetic patients, and they tend to inhibit the loss of fluid and water. The urinary excretion of aquaporin-2 (UAQP-2) in diabetic nephropathy is decreased due to the impaired cellular signaling of arginine vasopressin in collecting duct cells, and the changes of UAQP-2 can be used to estimate the recovery of circulatory blood volume during the therapeutic period in the patients with diabetic ketoacidosis.
作者 穆鑫 康白
出处 《国际内分泌代谢杂志》 2006年第2期113-115,共3页 International Journal of Endocrinology and Metabolism
关键词 水通道蛋白 糖尿病 水代谢 神经钙蛋白 Aquaporin Diabetes mellitus Water metatabolism Calcineurin
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  • 1P. Bardoux,M. Ahloulay,S. Le Maout,L. Bankir,M.-M. Trinh-Trang-Tan. Aquaporin-2 and urea transporter-A1 are up-regulated in rats with Type I diabetes mellitus[J] 2001,Diabetologia(5):637~645

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