摘要
目的:探讨隐匿性乙型肝炎的临床与病理特征。方法:应用荧光定量PCR及免疫组织化学方法,对79例不同HBV抗体阳性而肝功能反复异常者的临床与肝组织病理进行分析。结果:79例患者中,血清HBV DNA阳性27例(34.2%),肝组织中HBV DNA阳性59例(74.7%),差异具有显著性意义(χ2=26.1,P<0.01);肝组织病理检查结果显示慢性肝炎77例,其中大多数为轻中度损害,肝硬化早期2例;免疫组化检测结果显示肝组织中HB-sAg阳性11例,HBcAg阳性32例。结论:①隐匿性乙型肝炎患者肝组织中HBV DNA阳性率明显高于血清;②隐匿性乙型肝炎患者大多数存在不同程度肝损害,需要及时治疗。
Objective: To explore the clinical and pathological characteristic of patients with occult hepatitis B. Methods: HBV DNA were detected by real time fluorescence quantitative PCR. Specimen of the liver biopsy were examined by immuno chemistry. Results: HBV DNA were positive in the serum of 27 and in the specimen of the liver of 59 among the 79 patients, respectively; HBsAg and HBcAg in the specimen of the liver of 11 and 32 among the 79 patients were positive, respectively; 77 patients with chronic hepatitis and 2 patients with early hepatocirrhosis among 79 patients were showed by pathological examination of the liver biopsy. Conclusion: The positive rate of HBV DNA in the specimen of the liver is higher than that of in the serum; There are different damage in the liver of the patients with occult hepatitis B. These patients needto be treated.
出处
《中西医结合肝病杂志》
CAS
2006年第1期13-15,共3页
Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases