实验性肺螨病——尘螨性抗体水平动态变化的研究

OBSERVATION ON CHANGES OF SERUM SPECIFIC ANTIBODY IN EXPERIMENTAL PULMONARY ACARIASIS

本文通过以净化的活螨气管接种家兔建立肺螨病动物模型,并以甲硝达唑治疗两个疗程,于接种前、接种后6周、治疗后4周以葡萄球菌A蛋白酶联免疫吸附试验(SPA-ELSA)测定实验兔血清的尘螨性抗体。结果表明其抗体水平接种后较接种前明显升高,接种后10周未治疗组抗体水平继续增高达接种前的2.12倍,而治疗组明显下降,为未治疗组同期的24.62％。

Pured living mites were injected into the trachea of rabbits to form the animal model of pulmonary acariasis. 40 days later they were treated by Metronidazole. The specific serum antibody was determined with SPA-ELISA before injection, 6 weeks after injection and 4 weeks after treatment .The results showed that the specific antibody in injected rabbits serum was obviously increased compared with before injection and after treatment. The specific antibody in the non-treated group was 2.12 times that of the same group before injection, while in the treated group it was decreased markbly as 24.62% of the non-treated group in the same period.