血小板生成素及其研究进展

Progress on the Study of Thrombopoietin

血小板生成素（ＴＰＯ）是最近被描述的一种新型细胞因子，相对分子质量在３５×１０３以上，是一种糖蛋白．人和鼠ＴＰＯ成熟蛋白分别由３３２和３３５个氨基酸残基组成．ＴＰＯ的受体与造血生长因子受体超家族成员ｃ－Ｍｐｌ相关．ＴＰＯ不仅对巨核系祖细胞的增殖、分化具有明显的调控作用，而巨对血小板的生成同样具有促进作用．

Thrombopoietin (TPO) is a recently described novel cytokine produced in both liver and kidney. TPO protein secreted is glycoprotein with relative molecular mass of over 35 ku.Human and mouse mature TPO consist of 332 and 335 amino acid residues respectively. TPO receptor is related to c-Mpl which is a member of the hematopoietin receptor superfamily. TPO not only regulates the proliferation and differentiation of megakaryocyte progenitor cells, but also regulates the production of platelets.