期刊文献+

鼻咽癌面颈联合野配合后程超分割放疗疗效分析 被引量:6

Nasopharyngeal carcinoma treated with facial cervical portal and late-course hyperfractionation radiotherapy
原文传递
导出
摘要 目的 观察后程超分割治疗鼻咽癌的疗效及毒副反应。方法 93例鼻咽癌患者被随机分为后程超分割治疗组(后超组47例)和常规分割对照组(常规组46例)。均先行面颈联合野常规分割对穿照射Dr36Gy,20分次,4周,后超组缩野改用后程超分割照射,1.15~1.20Cy/次,2次/d,两次间隔时间6,8h,5d/周,鼻咽病灶总Dr74.8~76.7Gy,54分次,7.5周完成。对照组缩野后常规照射2.0Gy/次,1次/d,鼻咽灶总D169~72Gy,37~38分次,7.5周完成。颈部均为常规照射。结果 后超组和常规组鼻咽部肿瘤消退率分别为100%、96%(X^2=2.10,P〉0.05);1、3、5年肿瘤局部控制率分别为100%、98%、86%和100%、86%、54%(X^2=10.90,P〈0.01);1、3、5年生存率分别为100%、94%、85%和98%、84%、63%(X^2=8.70,P〈0.01)。两组放疗口腔黏膜反应无差别(X^2=1.00,P=0.800)。后超组复发率低于常规组(11%:30%;X^2=5.60,P〈0.05),而转移率无差别(12.8%:28.3%;X^2=3.40,P〉0.05)。结论 鼻咽癌后程超分割的局部控制率及长期生存率明显高于常规组,而急性毒性反应及复发转移无明显差别。 Objective To evaluate the clinical results and side reactions of nnsopharyngeal carcinoma (NPC) treated with facial cervical portal and late-course hyperfractionation radiotherapy. Methods From July 1996 to December 1997, 93 NPC patients were divided into conventional fractionation and hypeffractionation radiotherapy groups. In 47 patients, facial cervical lXa'tal was used until the dose of 36 Gy/20 fraction in 4 weeks, and then foUowed by hyperfractionation radiotherapy: 1.15-1.2 Gy/fraction, 2 fraction/day, with 6-8 hour interval between, to a total dose of 74.2-76.7 Gy in 7.5 weeks without changing the shape of the poaal. Forty-six patients were treated by conventional radiotherapy:2.0 Gy/fraction ,5 fraction/week, to a total dose of 69-72 Gy in 7.5 weeks. Results The regression rate was 100% ,96% in hyperfractionatiun and conventional fractionatiun radiotherapy group after 6 months of radiotherapy, respectively. The 1-,3-,and 5-year local control rate was 100%, 98% ,86% in the hyperfractionatiun radiotherapy group and 98%, 86%, 54% in the conventional fractionation group( P 〈 0.01). The 1-, 3-, and 5-year survival rate was 100%, 94%, 85 % in the hypeffractionation radiotherapy group and 98%, 84%, 63% in conventional fractionation(P 〈 0.01). Difference in acute mucusitis and late complications was not significant( P 〉 0.05). Conclusions In nasophryngeal carcinoma , the local control rate and survival rate are raised by hyperfractionation radiotherapy. But recurrence rate and distant metastasis rate are not significantly different.
出处 《中华放射肿瘤学杂志》 CSCD 北大核心 2006年第2期81-84,共4页 Chinese Journal of Radiation Oncology
基金 湖南省卫生厅科研基金资助(96-72)
关键词 鼻咽肿瘤/放射疗法 放射剂量分次 预后 Nasopharyngeal neoplasms/radiotherapy Dose fractionation Prognosis
  • 引文网络
  • 相关文献

参考文献13

二级参考文献30

  • 1罗伟,张恩罴,涂明耻,毛志达,曾祥发.改进鼻咽癌放射治疗技术的研究—(Ⅱ)临床近期疗效[J].癌症,1996,15(4):280-282. 被引量:21
  • 2张天泽 徐光炜.肿瘤学(第1版)[M].天津:天津科学技术出版社,1996.1554.
  • 3环素兰 中华医学会放射肿瘤学会.鼻咽癌超后程加速放射治疗Ⅱ期临床研究.第四届全国放射肿瘤学学术会议论文摘要汇编[M].武汉,1999,10..
  • 4[1]Wither HR,Tailor JMG,Maciejewski B.The hazard of accelerated tumor clonogen repopulation during radiotherapy.Acta Oncol ,1988,27:131~146.
  • 5[2]Sugawara T.Multiple fractions per day radiotherapy:Its background and current status .J Jpn Soc Ther Radiol Oncol,1997,9:263~276.
  • 6Teo P M,Int J Radiat Oncol Biol Phys,1999年,43卷,261页
  • 7马骏,癌症,1998年,17卷,274页
  • 8罗伟,癌症,1996年,15卷,280页
  • 9Yu K H,Clin Oncol,1994年,6卷,167页
  • 10崔念基,癌症,1992年,11卷,375页

共引文献192

同被引文献44

引证文献6

二级引证文献17

相关主题

;
使用帮助 返回顶部