恶性嗜铬细胞瘤的临床分析

Clinical analysis of malignant pheochromocytoma

目的提高对恶性嗜铬细胞瘤的诊治水平。方法总结22例恶性嗜铬细胞瘤患者临床资料。结果恶性嗜铬细胞瘤常见于男性,肾上腺外嗜铬细胞瘤恶性率较高,肿瘤大多直径大于7cm,且内部结构不均,瘤体常有粗肿瘤结节或多个结节。可存在无嗜铬组织浸润或转移的表现。结论常规病理难以区别肿瘤的良恶性,术后应长期观察肿瘤的生物学行为,是否发生无嗜铬组织的转移。对临床怀疑有恶性可能的肿瘤尽量行根治性肿瘤切除术。

[Objective] To review the experience with the diagnosis and treatment of malignant pheochromocytoma. [Methods] 22 case of malignant pheochromocytoma surgically treated were reviewed. [Results] Malignant ones occurred more frequently in the male patients and extraadrenal pheoehromocytomas, the malignant one usually exceeded 7.0 cm in diameter and uneven density in the tumor. [Conclusions] Histological findings are not consistent with the tumors＇s biological behaviors. Follow-up studies has been mandatory in malignant pheochromocytoma as well as in benign ones. To the case suspected or diagnosed malignant pheochromocytoma, prompt radical extirpation is the best means to achieve a long surival period.