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^(99m)Tc-HL91心肌乏氧显像评价急性心肌梗死患者缺血/存活心肌的可行性 被引量:2

Feasibility of hypoxia imaging with ~ (99m)technetium-HL91 in the evaluation of ischemic/viable myocardial tissues in acute myocardial infarction
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摘要 目的探讨急性心肌梗死(AMI)患者99mTcHL91乏氧心肌显像的可行性及其临床应用价值。方法15例AMI患者行Tl201和99mTcHL91双核素心肌显像,比较和描述两种核素心肌显像、缺血/存活心肌检测能力以及匹配方式。结果99mTcHL91可以提供较清晰的乏氧心肌图像并用于心肌节段分析;15例AMI患者行双核素显像,共255个节段,即刻Tl201显像示异常节段109个,占43%;99mTcHL91显像示阳性节段160个,占63%。即刻Tl201显像判断为异常的109个节段中,24hTl201延迟显像示40个(部分)可逆性节段(缺血/存活心肌),占37%;99mTcHL91显像示73个阳性节段,占67%,其中40个(部分)可逆节段均呈乏氧阳性显像。99mTcHL91显像检测缺血/存活心肌能力显著高于Tl201(P<0.01)。结论99mTcHL91可以用于AMI患者缺血/存活心肌乏氧成像并用于心肌节段分析。乏氧显像可为研究冠心病提供新手段。 Objective To evaluate the feasibility and clinical value of hypoxia imaging of myoeardium using simultaneous thallium-201 (Tl-201) and ^99mTc-HL91 imaging. Methods We recruited 15 patients with acute myocardial infarction (AMI) undergoing simultaneous imaging of ^99mTc-HL91 and Tl-201. Myocardium imaging, isehemie/viable myocardium detection and the different matching ways on these two imaging modalities were compared and described. Results ^99mTc-HL91 provided pretty discernible hypoxia imaging of myocardial tissues in AMI patients for further myocardial segment analysis. Fifteen AMI patients undergoing dual-isotope imaging had 255 segments in total. There were 109 abnormal segments on the immediate Tl-201 imaging, taking up 43a/00, and 160 posi rive segments on the 3 hour-^99mTc-HL91 imaging, taking up 63%. There were 40 (partially) reversible segments (ischemic/viable segments) on 24 h-delayed-Tl-201 imaging and 73 positive segments on 99mTc-HL91 imaging among 156 abnormal segments based on immediate Tl-201 imaging, in which the 40 (partially) reversible segments were all positive on the hypoxia imaging. The Tl-201 detection rate was 3?%,which was significantly lower than the ^99mTc-HL91 (67%)(P〈0. 01). Conclusions ^90mTc-HL91 can be used for hypoxia imaging of ischemic/viable myoeardium in AMI patients for further segment analysis. Hypoxia imaging may offer a new noninvasive approach for assessment of myocardial ischemia/viability.
出处 《江苏医药》 CAS CSCD 北大核心 2006年第4期301-303,共3页 Jiangsu Medical Journal
基金 江苏省"135"重点人才基金(RC2003019)
关键词 ^99MTC-HL91 铊-201 心肌梗死 乏氧 ^99mTechnetium-HL91 Thallium-201 Myocardial infarctiom Hypoxia
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