中年人群高血压病危险因素的流行病学调查

The study of epidemiology of middle age crowds at risk factors of hypertension in Datun Xuzhou

目的探讨徐州市大屯社区中年人群高血压病的流行现状及其主要危险因素,为高血压病防治策略的制订提供科学的依据。方法采取随机分层抽样的方法,从徐州大屯社区5万居民中抽取调查样本500例,入选382例,进行单因素、多因素logistic回归分析。结果(1)各暴露因素经单因素logistic回归分析,其中性别、年龄、饮酒、吸烟、绝经前妇女、高血压家族史、体重指数、尿酸、血糖、甘油三酯、低载脂蛋白A血症、载脂蛋白B、同型半胱氨酸、颈动脉内膜增厚及斑块形成在两组之间的差异具有显著性意义(P<0.05)。经计算,比数比(OR)值除绝经前妇女外均大于1,高血压与上述因素存在正相关(OR>1,P<0.05),高血压与绝经前妇女存在负相关(OR<1,P<0.05)。(2)各暴露因素行多因素logistic回归分析,高血压与体重指数、高血压家族史、甘油三酯、年龄存在正相关(OR>1,P<0.05),高血压与绝经前妇女存在负相关(OR<1,P<0.05)。结论体重指数、高血压家族史、甘油三酯、年龄、绝经可看作高血压病危险因素,绝经前妇女存在高血压保护因素。

Objective To study epidemiologic feature and risk factors of middle age crowds with hypertension in Datun Xuzhou and establish the prevention and cure strategy of hypertension. Methods The samples were collected with stratified random sampling method from 50 000 residents in Datun Xuzhou. Five hundreds samples of 35 to 60 years old people were selected from 10 administration units. 382 residents of Datun Xuzhou were investigated. All date were analysed with logistic regression model. Results （1） By single factorial logistic regression analysis, risk factors of hypertension were gender, age, drinking, smoking, family history of hypertension, body mass index（BMI）, iaric acid, blood glucose（Glu）, triglyceride（TG）, low apolipoprotein-A level, apolipoprotein-B, homocysteine and carotid atherosclerosis（OR〉 1, P〈 0. 05）. Perimenopause was the protection factor of hypertension（OR〈 1, P〈 0. 05）. （2） By multiple factorial logistic regression analysis, the hypertenssion was positively correlated with BMI, TG, age and family history of hypertension（OR〉1, P〈0.05） and perimenopause was the protection factor of hypertension （OR〈 1, P〈0. 05）. Conclusions BMI, TG, age and family history of hypertensslon are considered as the risk factors of hypertension, and perimenopause is a protective factor of hypertenssion in Datun Xuzhou.