内皮素－1在支气管哮喘发病机制中的作用

The role of endothelin-1 in the pathogenesis of asthma

本文应用特异性放射免疫分析法测定了２０名健康儿童及４３例支气管哮喘患儿血浆内皮素－１（ＥＴ－１）水平，用过敏性哮喘豚鼠进行验证。结果显示：轻中度哮喘患儿血浆ＥＴ－１与健康儿童组比较差异无显著性，而重症哮喘患儿血浆ＥＴ－１则明显增高，与健康对照组比较差异显著（Ｐ＜０．００１）；过敏性哮喘豚鼠血浆ＥＴ－１水平无明显变化，而其支气管肺泡灌洗液中却明显升高，与正常对照组有非常显著的差异（Ｐ＜０．０１），糖皮质激素及ＥＴ－１抗血清可降低ＥＴ－１水平，减轻哮喘发作。提示ＥＴ－１参与了支气管哮喘的发病机制。

Plasma endothelin-1(ET-1)levels in 43 cases of asthmatic childree and in 20 normal children were examined by RIA (radioimmunoassay).In addition,the plasma and bronchoalveolar lavage fluid(BALF)ET-1 levels in guinea-pigs with allargic asthma were