黄藤素在大鼠胃肠道中的吸收动力学

The absorption kinetics of Palmatine in stomach and intestines of rat

目的研究黄藤素在大鼠胃肠道中的吸收机理。方法采用HPLC检测黄藤素在大鼠的在体肠循环。结果黄藤素在全肠段均有吸收，但吸收都较差，在胃、小肠和结肠的每小时吸收百分率分别为7．95％、2．47％、2．40％，在20～200μg·ml^-1浓度范围内小肠吸收量与浓度呈线性关系。Ka值基本不变，吸收机制为被动转运。结论黄藤素的制剂研究与临床应用均应考虑其吸收特征。

OBJECTIVE To research the absorption characters of Palmatine in various intestinal segnents of rats.METHODS The absorption kinetics was investigated by the in situ perfusion method in rats and determined by HPLC. RESULTS Palmatine was absorbed badly at all segments of intestine in rats. The absorption pewentage in one hour （P%） at stomach, intestine and colon were 7.95%, 2.47% and 2.40% ,respectively. When the concentration of Peffusion solution was changed from 20 to 200 μg·ml^-1, the uptake of Palmatine in intestine increased. The absorption rate constant kept at the same level and Palmatine was absorbed mainly via passive transport mechanism. CONCLUSION The absorption characters of Palmatine would be considered in the preparation research and the clinical application.