肝细胞生长因子治疗肝脏损害116例疗效观察

Observation of Curative Efficacy of Hepatocyte Growth Factor in 116 Children with Liver Damage

目的观察肝细胞生长因子(HGF)治疗肝脏损害患儿的效果。方法将肝脏损害患儿204例随机分成两组,对照组在治疗原发病同时,选用能量合剂保肝;治疗组在此基础上选用HGF保肝、降酶治疗,观察治疗过程中肝脏回缩及降酶效果。结果疗程结束后HGF治疗组丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、总胆红素(TBIL)3项指标下降幅度明显大于对照组,治疗组总有效率达96.5%,而对照组总有效率为75.0%,治疗组明显优于对照组,有显著差异(χ2=5.27 P<0.05)。结论选用HGF治疗肝脏损害,可明显缩短病程,提高临床治愈率。

Objective To observe curative efficacy of hepatocyte growth factor（HGF） in treatment of children with liver damage. Methods Two hundred and four children with liver damage were divided randomly into control group and teatment group. The control group was chosed energy compounds at the same time of primary disease was treated, on the basis of the control group, the treatment group was chosed HGF to protect liver and decline enzyme,to observe efficacy of liver shrink and decline enzyme in the course of treatment. Results After the treatment, alanine aminotransferase（ ALT）, aspartate aminotransferase（AST） and total bilirubin（TBIL） decreased signifieantly in the treatment group with HGF. The total clinical efficacy was 96.5 %, while the total clinical efficacy of the control group was 75.0 %. The curative efficacy of treatment group surpassed that in the control group, the difference was obvious（X^2 = 5.27 P〈 0.05）. Conclusion HGF may shorten obviously clinical course and enhance curative efficacy.