1400例糖尿病患者血清胰岛相关抗体检测的临床意义

The Clinical Significance of Serum Autoantibodies to Pancreatic Islet in One Thousand and Four Hundreds Patients with Diabetes

目的观察胰岛细胞抗体(ICA)、胰岛素自身抗体(IAA)、谷氨酸脱羧酶抗体(GAD-A b)在1型、2型糖尿病(DM)和正常人群中阳性检出率,并探讨其临床意义。方法用EL ISA法检测血清ICA、IAA、GAD-A b。结果1、2型DM患者和正常人群血清中,ICA阳性率分别为39.0%,12.6%,3.8%;IAA阳性率分别为31.9%,16.3%,2.9%;GAD-A b阳性率分别为55.5%,16.8%,0.4%。结论结果提示ICA、IAA、GAD-A b与1型DM的发病高度相关;这些抗体的出现预示β细胞功能受损,有助于从2型DM中及早发现成人隐匿性自身免疫性糖尿病(LADA),以利临床早期应用胰岛素治疗,从而延缓胰岛β细胞功能的衰竭。

Objective To observe the ratio of positive about islet cell antibodies （ICA）,insulin autoantibodies （IAA） and glutamic acid decarboxylase antibodies （GAD-Ab） in type 1 diabetes,type 2 diabetes and control group. Methods ICA, IAA and GAD-Ab in serum were determined by ELISA. Results The positive ratio of ICA,IAA,and GAD-Ab was 39. 0%,31.9% and 55.5% in type 1 diabetes respectively;12.6%,16.3% and 16. 8% in type 2 diabetes respectively; 3.8%, 2. 9% and 0. 4% in control group respectively. Conclusion The positive results of these antibodies indicate the damage of β-cell function. The relations between these antibodies and type 1 diabetes will help to early screen out latent autoimmune diabetes of adults （LADA） from type 2 diabetes. For these patients,early treatment with insulin will retard the deterioration of pancreatic β islet cell function.