维生素B12混合溶液雾化吸入治疗急性放射性黏膜炎疗效观察

Effect of vitamine B12 mixed solution inhalation for acute radiation-induced mucosal injury

目的运用维生素B12混合溶液雾化吸入治疗鼻咽癌急性放射性黏膜炎,观察其临床治疗效果。方法 122例鼻咽癌患者接受放射治疗出现急性放射性黏膜炎,61例应用维生素B12混合溶液雾化吸入治疗作为治疗组,61例应用庆大霉素混合溶液雾化吸入治疗作为对照组。结果维生素B12混合溶液雾化吸入组患者急性放射性反应发生程度轻, 主要表现为黏膜损伤程度减轻,疼痛减轻,进食改善,放疗结束后体质量下降少,患者生活质量明显提高,放疗没有中断;而对照组放射性黏膜炎程度重,其中8例患者不得不中断放疗1周。结论运用维生素B12混合溶液雾化吸入治疗鼻咽癌急性放射性黏膜炎,效果满意,值得临床推广应用。

Objective To evaluate the therapeutic effect of inhalation of vitamine B12 mixed solution in treating acute radiation-induced mucosal injury. Methods Totally 122 patients with acute radiation-induced mucosal injury resulting from radiotherapy were divided into two equal groups and received vitamine B12 mixed solution inhalation and gentamycin sulfate mixed solution inhalation, respectively. Results The patients receiving inhalation ofvitamine B12 mixed solution showed favorable response to the treatment and the mucosal injury was alleviated as manifested by relieved pains, improved appetite and lessened body weight loss, which allowed uninterrupted administration of radiotherapy. In patients treated with inhalation of gentamycin sulfate mixed solution, by contrast, the mucosal injury was serious and in 8 patients radiotherapy had to be suspended for acute radiation-induced mucosal injury. Conclusion Vitamine B12 mixed solution inhalation can be an effective treatment for acute radiation-induced mucosal injury.