奥沙利铂的神经毒性和防治进展

Oxaliplatin Induced Neurotoxicity: Characteristic and Therapy

奥沙利铂(oxaliplatin,LOHP)是第3代铂类抗癌药物,抗癌谱广、毒副反应轻微是其主要特点。但该药的外周神经毒性发生率却高达90%,是其剂量限制性毒性。神经毒性分为两种:以遇冷后表现加重为特征的急性神经毒性以及与顺铂相似的慢性的累积神经毒性。该文就LOHP所引起的神经毒性的临床和电生理表现、发生机制及防治方法进行综述。

Oxaliplatin, the third generation of the platinum based chemotherapy agent, is effective in the treatment of multiple solid tumors and is also quite safe. However, there is a high incidence of peripheral neurotoxiciy, which is dose-limiting. Oxaliplatin induces two distinct forms of neurotoxicity： an acute syndrome that is triggered or aggravated by exposure to cold, and chronic cumulative sensory neurotoxicity which in nature resembles characteristics of cisplatin associated neurotoxicity. In this article, the clinical manifestations, electrophysiologic abnormalities, mechanism of neurotoxicity and therapy are reviewed.