妊娠糖尿病孕妇血浆抵抗素水平及其与胰岛素和血糖关系的研究

Maternal plasma resistin levels and their relationship to insulin and glucose in pregnant women with gestational diabetes mellitus.

目的探讨妊娠期糖尿病(GDM)孕妇血浆抵抗素水平及其与胰岛素和血糖的关系。方法采用竞争性酶联免疫吸附法(ELI SA)检测25例GDM组孕妇和30例正常孕妇空腹血浆抵抗素水平;采用葡萄糖氧化酶法测定两组孕妇空腹血糖水平;采用电化学发光法测定两组孕妇的空腹血浆胰岛素水平。结果(1)GDM组孕妇空腹血浆抵抗素水平为(15.32±4.26)μg/L,正常妊娠组孕妇为(11.08±1.52)μg/L两组比较,差异有极显著性(P<0.01);(2)GDM组孕妇空腹血浆胰岛素,血糖水平分别为(13.18±3.25)m IU/L,(9.13±1.34)mmol/L正常妊娠组孕妇分别为(9.10±3.41)m IU/L,(4.72±1.05)mmol/L。两组比较差异有极显著性(P<0.01);(3)GDM组孕妇血浆抵抗素水平与胰岛素、血糖水平呈明显的正相关关系,相关系数(r)分别为0.812,0.573;正常妊娠组孕妇则无相关性。结论GDM孕妇血浆抵抗素水平升高,其抵抗素水平的高低与空腹血浆胰岛素及血糖水平相关。

Objective： To investigate the changes in resistin levels and the relationship between the substoule and insulin glucose in pregnant women with gestational diabetes mellitus （GDM） . Methods： ELISA was used to measure the resistin levels at fating in 25 patients with GDM and 30 normal pregnant women, In each pregnant women, fasting glucose levels were measured by glucose oxidase method. Fasting plasma insulin levels by eleetrochemilum ineseent immanoassays. Results： The Plasma resistin Levels in pregnant women with GDM and normal pregnant women were （ 15.32 ±4. 26） μg/L and （ 11.08 ± 1.52） μg/L, respectively, Suggesting the plasma resistin levels were significantly higher in pregnant women with GDM than in normal controls. The levels of fasting plasma insuhn and plasma glucose levels were （ 13.18 ±3.25） mIU/L, （9. 13± 1.34） mmol/L, where as the corresponding values in Norman controls were （9. 10 ±3.41） mIU/L （4. 72 ± 1.05） mmol/L. The same as the plasma insulin and Glucose levels were significantly higher in pregnant women with GDM than in normal controls. A positive correlation was found between maternal plasma resistin and fasting plasma insulin levels in pregnant women with GDM （ r =0. 812, P 〈0. 01 ）, A positive correlation was also found between maternal resisfin concentrations and glucose levels in women with GDM （ r = 0. 573 P 〈 0. 01 ） . Conclusion： Resistin levels are elevated in pregnant women with GDM compared with healthy pregnant women, a positive levels and fasting insulin levels, as well as between the maternal resistin levels and plasma glucose levels in women with GDM.