阻塞性睡眠呼吸暂停低通气综合征和肥胖及正常体重人群血清瘦素水平的研究

A study of the level of serum leptin in patients with obstructive sleep apnea-hypopnea syndrome and obesity and patients with normal body mass

目的:探讨阻塞性睡眠呼吸暂停低通气综合征(OSAHS)、肥胖和正常体重人群的血清瘦素水平。方法:将经PSG检测的患者分为OSAHS组(53例)和单纯肥胖组(41例),另选正常体重者(正常体重组)62例,用放射免疫法测定3组的血清瘦素水平,同时测量每例受检者的身高、体重、颈围、腰围和臀围。结果:①无论男性还是女性,OSAHS组和单纯肥胖组的血清瘦素水平均比正常体重组高(均P<0.05);OSAHS组血清瘦素水平[男(8.06±2.58)μg/L,女(12.83±2.67μg/L)]均高于单纯肥胖组[男(5.75±1.27)μg/L,女(9.83±1.99μg/L)](均P<0.05)。②单纯肥胖组及OSAHS组血清瘦素水平分别与体质指数(BMI)呈显著正相关(均P<0.01),OSAHS组血清瘦素水平与AHI、颈围及腰臀围比(WHR)也呈显著正相关(均P<0.01)。结论:单纯性肥胖患者血清瘦素水平升高与机体内发生瘦素抵抗有关;OSAHS患者的血清瘦素水平与AHI呈正相关,说明OSAHS本身可能是引起血清瘦素升高的因素之一,瘦素可能有兴奋呼吸中枢的作用。

Objective：To explore the level of serum leptin in patients with obstructive sleep apnea-hypopnea syndrome （OSAHS） and obesity and patients with normal body mass. Method：Polysomnography（PSG） was performed in 53 patients with OSAHS and in 41 simple obesity and in 62 patients with normal body mass. The level of serum leptin was detected by radioimmunoassay. The stature, weight, neck collar, hip circumference, waistline were measured. Result：①Serum Ieptin level in patients with OSAHS and obesity was higher than patients with normal body mass. At the same time, serum leptin level in patients with OSAHS was higher than obesity （ P 〈 0.05）. ② Serum leptin levels were positive significantly correlated with BMI in both OSAHS patients and simple obesity, but only the leptin level in patients with OSAHS was significantly correlated with apnea and hypopnea index （AHI） and proportion of neck circumference and waist-hip ratio （WHR）. Conclusion： The rise of the serum leptin level in obesity was resisted of leptin. The serum leptin level of patients with OSAHS correlated with AHI shows that OSAHS maybe one reason of arosing serum leptin＇s rising. Leptin could stimulate aspiratory centrum.