梗阻性黄疸患者的尿前列腺素与肾功能

URINARY PROSTAGLANDINS AND RENAL FUNCTION IN OBSTRUCTIVE JAUNDICE PATIENTS

本文通过测定８例梗阻性黄疸患者术前、术后２４小时尿中ＰＧＩ２和ＴＸＡ２的稳定代谢产物６－ｋｅｔｏ－ＰＧＦ１α、ＴＸＢ２及２４小时尿量（Ｕｖ）、内生肌酐清除率（Ｃｃｒ），探讨前列腺素对肾功能的影响。结果显示：术前６－ｋｅｔｏ－ＰＧＦ１α明显高于对照组（Ｐ＜０．０５），ＴＸＢ２、Ｕｖ、Ｃｃｒ较对照无明显变化（Ｐ＞０．０５）。术后一周，ＴＸＢ２明显增高（Ｐ＜０．０５），ＰＧＩ２、Ｕｖ、Ｃｃｒ明显下降（Ｐ＜０．０５）。术后两周，ＴＸＢ２逐渐下降，６－ｋｅｔｏ－ＰＧＦ１α、Ｕｖ、Ｃｃｒ恢复术前水平，结果认为：前列腺素对维持肾血流及肾小球滤过率有重要作用。

We studied that prostaglandins hadinfluence on kidney function by measuring in 6-keto-PGF1α、TXB2 in 24 hours urine the stable metabolite of PGI2 and TXB2,UV and Cor of 24 hours urine in 8 patients with obstructive jaundice before and after opration.The result showed preoperative 6-keto-PGF1αwas much higher than that of the control group markedly,no obvious changes in TXB2、Uv、Ccr.One week after operation TXB2 increased,UV and Ccr decreased obviously.Two weeks after operation TXB2 decreased gradually and PGI2、Uv、Cxr restored.We concluded it was very important that prostaglandins could sustain kidnedy blood flow and glomerular filtration rate.