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桂枝汤对体温双向调节作用的机理探讨──对下丘脑乙酰胆碱和去甲肾上腺素作用的影响 被引量:19

The Mechanism of Dual-Directional Thermoregulation by“Guizhi Tang”(桂枝汤Decoction of CinnamonTwigs)---Effect on the Action of Acetylcholine and Norepinephrine in Hypothalamus
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摘要 大鼠脑室注射去甲肾上腺素20ng/只,能快速引起体温下降;口饲给予10g/kg桂枝汤,能部分拮抗去甲肾上腺素的降温作用。大鼠脑室注射乙酰胆碱1mg/只,能使体温升高;口饲给予桂枝汤,能阻断其发热反应。结果提示,桂枝汤可能通过促进下丘脑中过量去甲肾上腺素或乙酰胆碱的灭活,拮抗或部分拮抗它们的降体温或发热作用。 After 20ng norepinephrine administered intracerebroventriculary(icv),the body temperature of rats was rapidly dropped and 15 minutes laterminmized and the value of the area under the body temperature-time curve in 0.67 hours(TRI(0.67))was-0. 92±0.26. The hypothermic action of norepinephrine was inhibited by 10g/kg Guizhi Tang per os,with TRI(0.67) being-0.50±0.10(P<0.01).1mg of Acety-choline icv was observed to cause hyperthermia。The peak was reached in 2 hours,and TRI(3.0) was 1.25±0.52.Guizhi Tang p.o. could,on the other hand,bolck hyperthermia reaction induced by acetylcholine and the TRI(3.0) was 0.34±0.49(P<0. 01).The evi-dence indicated that Guizhi Tang could promoted degradation of excessive nore pinephrine or acetycholibne in hypothalamus。
出处 《中国实验方剂学杂志》 CAS 1996年第2期8-10,共3页 Chinese Journal of Experimental Traditional Medical Formulae
基金 国家中医药管理局资助
关键词 方剂 桂枝汤 体温调节 去甲肾上腺素 乙酰胆碱 Guizhi Tang(Decoction of Cinnamon Twigs) Thermoregulation Norepinephrine Acetycholine。
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