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扶正化瘀复方药物血清对大鼠肝贮脂细胞增殖及胶原合成的影响 被引量:67

Effect of Sera Containing Fuzheng Huayu(FZHY)Decoction on Ito Cell Proliferation and Collagen Synthesis in Rats
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摘要 采用正常大鼠灌胃给药、分离血清而体外作用培养细胞的血清药理学方法,探讨扶正化瘀方对培养大鼠贮脂细胞功能的影响。结果表明该复方血清无明显细胞毒性,抑制细胞增殖及胶原合成,而且该作用与复方的体内给药方式、给药剂量、取血时间、药物血清作用浓度等有一定关系。 Using a serum pharmacological method that the sera,derived from therats orally taking FZHY,were incubated with culturd ito cells(Fat-storing cells,passage1)of the rats,it wasinvestigated that FZHY affected ito cell functions such a cell prolif-eration and collagen synthesi.The results showed that the FZHY sera had no cytotoxi-city towards the ito cells inhibited cell proliferation and collagen synthesis。Further-more,this inhibition had a positive relation with administration and dosage of the FZHYdecoction bood-taken tine,and the concentration of the sera in the culture,was conclud-ed that the inhibit ion of FZHY on ito cells may be one of mechanisms through whichliver fibrosis was prevented with it
机构地区 上海中医药大学
出处 《中国实验方剂学杂志》 CAS 1996年第2期16-19,共4页 Chinese Journal of Experimental Traditional Medical Formulae
基金 国家自然科学基金
关键词 方剂 扶正化瘀方 贮脂细胞 胶原 Fuzheng Huayu(FZHY )Decoction,Serum Pharmacology,Ito Cell(Fat-storing cell),Anti-liver Fibrosis
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参考文献2

  • 1徐列明,刘成,刘平,刘成海,李风华,顾宏图,成令忠.一种稳定和高产的肝贮脂细胞分离法[J]细胞生物学杂志,1995(03).
  • 2刘成,刘平,胡义杨,朱剑亮,徐列明,薛惠明.扶正祛瘀方抗肝纤维化的研究[J].中医杂志,1994,35(10):602-604. 被引量:35

二级参考文献6

  • 1王杰军,中华消化杂志,1992年,12期,30页
  • 2张鲁榕,中华消化杂志,1991年,11期,67页
  • 3刘成,中医杂志,1991年,32卷,404页
  • 4刘平,上海市中医药研究院学报,1990年,4卷,2期,41页
  • 5唐民圭,中国病理生理杂志,1987年,3期,252页
  • 6张鲁榕,Hepatology,1985年,5卷,638页

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