摘要
采用正常大鼠灌胃给药、分离血清而体外作用培养细胞的血清药理学方法,探讨扶正化瘀方对培养大鼠贮脂细胞功能的影响。结果表明该复方血清无明显细胞毒性,抑制细胞增殖及胶原合成,而且该作用与复方的体内给药方式、给药剂量、取血时间、药物血清作用浓度等有一定关系。
Using a serum pharmacological method that the sera,derived from therats orally taking FZHY,were incubated with culturd ito cells(Fat-storing cells,passage1)of the rats,it wasinvestigated that FZHY affected ito cell functions such a cell prolif-eration and collagen synthesi.The results showed that the FZHY sera had no cytotoxi-city towards the ito cells inhibited cell proliferation and collagen synthesis。Further-more,this inhibition had a positive relation with administration and dosage of the FZHYdecoction bood-taken tine,and the concentration of the sera in the culture,was conclud-ed that the inhibit ion of FZHY on ito cells may be one of mechanisms through whichliver fibrosis was prevented with it
出处
《中国实验方剂学杂志》
CAS
1996年第2期16-19,共4页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家自然科学基金
关键词
方剂
扶正化瘀方
贮脂细胞
肝
胶原
Fuzheng Huayu(FZHY )Decoction,Serum Pharmacology,Ito Cell(Fat-storing cell),Anti-liver Fibrosis