胰腺癌患者手术前后血清SIL－2R和TNF水平检测及意义

THE DETECTION AND SIGNIFICANCE ON THE LEVELS OF SOLUBLE INTERLEUKIN 2 RECEPTOR AND TUMOUR NECROSIS FACTOR IN PATIENTS WITH PANCREASES CANCER BEFORE AND AFTER OPERATION

采用双抗体夹心ＥＬＩＳＡ法检测了６０例胰腺癌患者手术前后血清可溶性白细胞介素－２受体（ＳＩＬ－２Ｒ）和肿瘤坏死困子（ＴＮＦ）水平。结果表明胰腺癌患者血清ＳＩＬ－２Ｒ和ＴＮＦ水平均明显高于正常人（Ｐ＜０．０１），且与胰腺癌临床分期有明显相关性。行根治性手术者术后１月血清ＳＩＬ－２Ｒ和ＴＮＦ水平明显降低（Ｐ＜０．０１），而行姑息性手术者则无显著性降低（Ｐ＞０．０５）。结果提示，动态观测血清ＳＩＬ－２Ｒ和ＴＮＦ水平变化，可作为胰腺癌患者病情判断。

The serum levels of soluble interleukin 2 receptor(sIL 2R) and tumour necrosis factor(TNF) before and after operation in 60 patients with pancrease cancer were determined with an enzyme linked immunosorbent assay(ELISA). The results showed that the sIL 2R and TNF levels of patients with pancrease cancer were much higher than those of normal controls(p<0.01), and the serum sIL 2R and TNF levels of the patients with pancreas cancer were intimately associated with clinical stages. The two levels were significantly reduced after radical operation(p<0.01), but not significantly reduced after paliative operation(p>0.05). These results suggested that alteration in the serum sIL 2R and TNF levels can have clinical and prognostic significance in patients with pancrease cancer.