阿片类药预处理对心脏的保护作用

Advance in cardioprotection of opioid preconditioning

Opioids’ preconditioning can elicit cardiac protective effects like ischemic preconditioning but no paradoxical ischemic stimulation.The clinically used narcotic analgesics like morphine,fentanyl and remifentanil can relieve injury through δor κ opioids receptors.The mechanisms include G-proteins,protein kinase C,reactive oxygen species,inducible nitric oxide synthase,and nuclear transcription factor-κB,and the mitochondrial ATP-sensitive potassium channel is thought as the putative effect site. Although opioids seem to have promising properties in animal experiments,no direct extrapolation should made from theoretical experimental knowledge,and the effects of each preconditioning protocol need to be evaluated in the patients.

Opioids＇preeonditioning can elicit cardiac protective effects like isehemie preconditioning but no paradoxical isehemic stimulation. The clinically used narcotic analgesics like morphine , fentanyl and remifentanil can relieve injury through δor κ opioids receptors . The mechanisms include G-proteins, protein kinase C, reactive oxygen species , inducible nitric oxide synthase, and nuclear transcription faetor-κB, and the mitochondrial ATP-sensitive potassium channel is thought as the putative effect site. Mthough opioids seem to have promising properties in animal experiments, no direct extrapolation should made from theoretical experimental knowledge, and the effects of each preconditioning protocol need to be evaluated in the patients.