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65例1型糖尿病肾病患者血C反应蛋白和白介素6的改变 被引量:3

The C-reactive Protein and Interleukin-6 in 65 Patients with Type 1 Diabetic Nephropathy
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摘要 目的分析1型糖尿病肾病患者血C反应蛋白和白介素6浓度的改变。方法将65例1型糖尿病患者分为无蛋白尿组(n=28)、微量蛋白尿组(n=23)和大量蛋白尿组(n=14)。观测患者血糖、血脂、C反应蛋白(CRP)和白介素6(IL-6)的改变。结果CRP在微量蛋白尿和大量蛋白尿组较无蛋白尿组增高,并与蛋白排泄率有关。IL-6的升高与肾病程度、HDL和蛋白排泄率相关。结论提示1型糖尿病肾病可能伴有体内炎症反应变化。 Objective To investigate the changes Of C - reactive protein and interleukin - 6 in 65patients with type 1 diabetic nephropathy. Methods 65 patients with type 1 diabetic were divided into three groups. Normoalbuminuria ( n = 28 ), microalburninuria( n = 23) and macroalbuminuria ( n = 14). Results C- reactive protein (CRP) was associated with albumin excretion rate (AER). And it was higher in micro - and macroalbuminuric patients compared to normoalbuminuria. HDL - cholesterol and duration of diabetes were independently associated with interleukin - 6. Conclusions CRP and interlukin - 6 are corelation with the diabetic nephropathy in type 1 diabetes. The predictive value needs to be assessed.
作者 裴宁 李益明
出处 《实用全科医学》 2006年第3期265-266,共2页 Applied Journal Of General Practice
关键词 1型糖尿病 糖尿病肾病 C反应蛋白 白介素6 Type 1 diabetes mellitus Diabetic nephropathy C- reactive protein Interleukin- 6
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  • 1C. G. Schalkwijk,D. C. W. Poland,W. van Dijk,A. Kok,J. J. Emeis,A. M. Dr?ger,A. Doni,V. W. M. van Hinsbergh,C. D. A. Stehouwer. Plasma concentration of C-reactive protein is increased in Type I diabetic patients without clinical macroangiopathy and correlates with markers of endothelial dysfunction: evidence for chronic inflammation[J] 1999,Diabetologia(3):351~357

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