摘要
目的分析1型糖尿病肾病患者血C反应蛋白和白介素6浓度的改变。方法将65例1型糖尿病患者分为无蛋白尿组(n=28)、微量蛋白尿组(n=23)和大量蛋白尿组(n=14)。观测患者血糖、血脂、C反应蛋白(CRP)和白介素6(IL-6)的改变。结果CRP在微量蛋白尿和大量蛋白尿组较无蛋白尿组增高,并与蛋白排泄率有关。IL-6的升高与肾病程度、HDL和蛋白排泄率相关。结论提示1型糖尿病肾病可能伴有体内炎症反应变化。
Objective To investigate the changes Of C - reactive protein and interleukin - 6 in 65patients with type 1 diabetic nephropathy. Methods 65 patients with type 1 diabetic were divided into three groups. Normoalbuminuria ( n = 28 ), microalburninuria( n = 23) and macroalbuminuria ( n = 14). Results C- reactive protein (CRP) was associated with albumin excretion rate (AER). And it was higher in micro - and macroalbuminuric patients compared to normoalbuminuria. HDL - cholesterol and duration of diabetes were independently associated with interleukin - 6. Conclusions CRP and interlukin - 6 are corelation with the diabetic nephropathy in type 1 diabetes. The predictive value needs to be assessed.
出处
《实用全科医学》
2006年第3期265-266,共2页
Applied Journal Of General Practice
关键词
1型糖尿病
糖尿病肾病
C反应蛋白
白介素6
Type 1 diabetes mellitus
Diabetic nephropathy
C- reactive protein
Interleukin- 6