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胰腺癌组织黏蛋白MUC_1表达的意义 被引量：8

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摘要 目的:探讨MUC1在胰腺癌组织中的表达及其在胰腺癌诊断和治疗中的意义．方法:采用免疫组化方法检测43例原发性胰腺癌组织和15例正常胰腺组织中MUC1的表达．结果:MUC1在胰腺癌组织中的阳性表达率为 67．4％,明显高于正常胰腺组织(20．0％),与正常胰腺组织之间存在统计学差异(x2=8．293, P<0．01)．MUC1在胰腺癌组织中阳性表达率与胰腺癌淋巴结转移及TNM分期存在关联(x2= 5．180,P=0．023;x2=4．289,P=0．038)．结论:MUC1可作为胰腺癌患者预后评价指标,并可用于诊断及作为免疫治疗的靶抗原．
作者 高志强 丁志强 陈勇军 李晓云 罗强 陈忠
机构地区 华中科技大学同济医学院附属同济医院胆胰外科
出处 《世界华人消化杂志》 CAS 北大核心 2006年第9期923-926,共4页 World Chinese Journal of Digestology
关键词 胰腺癌 黏蛋白 MUC1 免疫组化
分类号 R735.9 [医药卫生—肿瘤]
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共引文献71

同被引文献80

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  • 3王义,高军,满晓华,龚燕芳,李兆申.胰腺细针穿刺标本中粘蛋白MUC1、MUC5AC的临床意义[J].胰腺病学,2007,7(2):110-112. 被引量：1
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引证文献8

二级引证文献16

世界华人消化杂志
2006年 第9期

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