烟酰胺对四氧嘧啶糖尿病模型动物的预防作用

Preventive Effect of Nicotinamide on Alloxan-induced Diabetic Rats

研究烟酰胺对四氧嘧啶诱发糖尿病的预防作用。于四氧嘧啶造型前给予不同剂量烟酰胺,或造型前不同时间给予等剂量烟酰胺。结果,烟酰胺0.6、1.8 g/kg 体重先于四氧嘧啶90分钟使用能显著降低糖尿病发生率。并且,即使发生糖尿病,其血糖均值也低于对照组。烟酰胺对四氧嘧啶诱发糖尿病的预防与其给药时间有关,在四氧嘧啶诱导前45分钟和90分钟给予烟酰胺有效。前1分钟无明显效果。烟酰胺对正常动物葡萄糖耐量无明显影响。

The preventive effects of nicotinamide on alloxan-indueed diabetic rats were studied. Nieotinamide,in doses of 0.6 and 1.8 g/kg body weight,given orally to SD rats 90 minutes before al- loxan has significantly lowered the morbidity of alloxan-induced diabetes.With nocotinamide given 1 minute preceding the alloxan injection,no significant protection was observed.However,by increas- ing the time intervals between the nicotinamide and alloxan administration to 60 or 90 minutes signifi- cant protection was observed.Nicotinamide did not alter the glucose tolerance test of normal rats.