1Pessin J E,Saltiel A R.Signaling pathways in insulin action:molecular targets of insulin resistance[J].J Clin Invest,2000,106:165~169.
2Weyer C,Tataranni PA,Bogardus C,Pratley RE.Insulin resistance and insulin secretory dysfunction are independent predictors of worsening of glucose tolerance during each stage of type 2 diabetes development[J].Diabetes Care,2001,24(1):89~94.
3Butler AE,Janson J,Bonner-Weir S,et al.B-cell deficit and increased B-cell apoptosis in humans with type 2 diadetes[J].Diabetes,2003,52:102~110.
4Butler AE,Jang J,Gurlo T,et al.Diabetes due to a progressive defect in beta-cell mass in rats transgenic for human islet amyloid polypeptide:a new model for type 2 diabetes[J].Diabetes,2004,53,1509~1516.
5Hannele Yki-Jarvinen.Toxicity of Hyperglycaemia in Type 2 Diabetes[J].Diabetes Metab.Rev.1998;14:S45~S50.
6Moran A; Zhang HJ; Olson LK,et al.Differentiation of glucose toxicity from beta cell exhaustion during the evolution of defective insulin gene expression in the pancreatic islet cell line[J],HIT-T15,J Clin Invest.1997;99:534~539.