摘要
应用丹参对２４例冠心病患者进行治疗，观察治疗前后患者血清中脂质过氧化物（ＬＰＯ）和超氧化物歧化酶（ＳＯＤ）含量的变化，并与２０例健康人作对照，结果显示：冠心病患者血清中ＬＰＯ明显高于健康人（Ｐ＜０．０１），冠心病患者血清中ＳＯＤ明显低于健康人（Ｐ＜０．０１）；采用丹参治疗后，患者血清中ＬＰＯ明显降低（Ｐ＜０．０１），而血清ＳＯＤ则有较明显的升高（Ｐ＜０．０５）。丹参降低ＬＰＯ，提高血清ＳＯＤ活性的机理可能与抗血小板聚集、降低血粘度、改善心肌缺血、保护心肌细胞膜有关。提示丹参可作为一良好的外源性氧自由基清除剂。
Twenty-four patients of coronary heart disease(CHD) were treated with Salvia miltiorrhiza(SM) and the change of SM on serum lipid peroxide(LPO), superoxide dismutase(SOD) after treatment were observed. The results were compared with that of control group consisted of 20 healthy persons, it showed that before treatment, the serum LPO of patient was significantly higher than that of control group and the SOD of patient was lower than that of healthy subjects (P<0.01). After treated with SM, the LPO level decreased and SOD activity increased significantly. The mechanism might be correlated with the effect of SM in inhibiting platelets aggregation, reducing blood viscosity, improving myocardial ischemia and protecting cytomembrane. It suggested that SM could be regarded as a good exogenous scavenger of oxygen free radical.
出处
《中国中西医结合杂志》
CSCD
北大核心
1996年第5期287-288,共2页
Chinese Journal of Integrated Traditional and Western Medicine
关键词
丹参
冠心病
脂质过氧化物
超氧化物歧化酶
治疗
Salvia miltiorrhiza
coronary heart disease
lipid peroxide
superoxide dismutase
