上海市区膀胱癌病例-对照研究

A POPUALTION-BASED CASE-CONTROL STUDY ON BLADDER CANCER IN SHANGHAI

在1987～1989年上海市区开展的一次基于全人群的膀胱癌病例一对照研究，共完成调查男女性新发病例377例及对照398例．结果显示，吸烟者有显著升高的膀胱癌危险度（男性：OR=1．7，95％CI为1．2～2.5；男女性;OR=1．6，95％CI为1．1～2．2），尤其烟龄在43年以上者，其危险度可高达2．5倍以上．职业暴露于有机溶剂者发生膀胱癌的危险性也有显著升高，而遗传、尿路感染史与膀胱癌的关系也较为密切．一些新鲜的蔬菜和水果对膀胱癌有保护作用．未发现酒精、咖啡和茶的消耗与膀胱瘤有关．

A case-control study on bladder cancer was carried out in Shanghai urban area with 377 incident cases from January 1987 to December 1989.Each case was matched for sex and age(within 5 years)t0 1 population-based control.For smokers,there was an elevated odds ratio in male [OR = 1.7 (1.2-2. 5)]. Odds ratio for years of cigarettes smoking inc.eased to ap-proximately 2.5 for smokers of more than 43 years. After adjustment for age, income and numbers of cigarettes smoked per day, most of occupational factors examined were not found to be associated with risk of bladder cancer,except esposure to gasoline and organic solvents.In addition,significant associations was also found for infection of the lower urinary tract and familial history of cancer.There was decrease in risks with increasing levels of consumption of some fresh vegetables and fruits. Finally,no statistically significant or consistent differ-ences were obtained between cases and controls in regard to cci,sumption of coffee,wine and tea.