高氧液对心肺复苏后急性脑缺血-再灌注损伤的保护作用

Protective effect of hyperoxia liquid on acute cerebral reperfusion injury following cardiopulmonary resuscitation

目的探讨高氧液对心肺复苏后急性脑缺血-再灌注损伤的保护作用。方法随机将23例心肺复苏后患儿分为高氧液组11例(高氧液+常规综合治疗)和常规组12例(单纯常规综合治疗)。分别于治疗前后不同时间点检测患儿血清超氧化物歧化酶(SOD)、丙二醛(MDA)水平以及血氧分压(PaO2)、血氧饱和度(SaO2)变化,并以格拉斯哥昏迷评分(GCS)量表判断临床疗效。结果与常规组比较,高氧液组PaO2和SaO2明显升高(P<0.01);GCS评分显著增高(P<0.05或0.01);血清SOD活性显著升高(P<0.01)、MDA含量显著降低(P<0.05或0.01)。结论早期使用高氧液治疗有助于改善脑组织缺血缺氧,减轻脑组织脂质过氧化损害程度,对心肺复苏后急性脑缺血-再灌注损伤具有保护作用。

Objective To investigate the protective effects of hyperoxia liquid on acute cerebral reperfusion injury following cardiopulmonary resuscitation. Methods Twenty-three inpatients after cardiopulmonary resuscitation were divided into two groups：hyperoxia liquid group （n = 11） underwent hyperoxia liquid therapy and conventional group （ n = 12） underwent conventional treatment. The changes of PaO2, SaO2 and amount of SOD and MDA in plasma were measured in different time before and after the treatment, The clinical curative effects were judged by glasgow coma scale （GCS）. Results Compared with conventional group, there were significant increases in PaO2, SaO2,GCS（P〈0.05 or P〈 0.01）, the amount of SOD was significantly higher while the amount of MDA was lower significantly in hyperoxia liquid group（ P 〈 0.05 or P 〈 0.01 ）. Conclusion Early application of hyperoxia liquid can decrease brain anoxia and the damage of lipid peroxidation. It has obviously protective effects on acute cerebral reperfusion injury following cardiopulmonary resuscitation.