SARS冠状病毒主要结构蛋白的研究进展

Advances in the Research on the Main Structural Proteins of SARS-CoV

严重急性呼吸综合征(SARS)因其传染性强、危害性大而受到广泛关注。世界各国密切合作,在对SARS的研究方面取得了许多突破。本文针对2005年前后的相关研究进展,综述了对S、N、M和E等4种SARS冠状病毒的结构蛋白的功能、实际应用等研究情况,其中对S、N蛋白进行了更为详细的介绍,重点阐述了主要结构蛋白的特征性功能区域、特异性蛋白、特征性反应、实验研究技术的改进以及疫苗研发等进展。

The severe acute respiratory syndrome（SAILS） has spread in about 30 countries and regions worldwide. Much attention has paid to this deadly disease due to its high infectivity. In response to this outbreak, a number of laboratories worldwide collaborate internationally, and make a great deal of research breakthrough. In this review, the main structural protein S, N, M and E were briefly summarized, focusing on investigation advances about their function and research of SARS vaccine.