摘要
目的:探讨子宫颈癌多药耐药(MDR)基因产物(P_糖蛋白,P_gp)的表达及其意义。方法:采用S_P免疫组化法测定38例子宫颈癌,16例子宫颈上皮内肿瘤(CIN)和16例正常子宫颈组织的P_gp表达。结果:上述组织均有P_gp表达,子宫颈癌强阳性表达率较正常子宫颈组织高(P<0.05),但与CIN比无统计学意义。P_gp强阳性表达与子宫颈癌临床分期、肿瘤分化程度以及病理组织学类型不相关。结论:子宫颈癌对抗肿瘤药物具有先天耐药性,P_gp阳性表达是子宫颈癌化疗疗效不佳的原因之一。
Objective: To study the expression and significance of P-glycoprotein(P-gp)in cervical carcinoma. Methods: The P-gp expression of tissues in 38 cases of cervical carcinoma, 16 cases of cervical intraepithelial neoplasm (CIN)and 16 cases of normal cervix was detected by SiP immunohistochemical method. Results: The P-gp expression was found in all tissues mentioned above. The strongly positive staining in cervical carcinoma was higher than that of the normal cervix( P 〈 0.05). Conclusion: There is primary multidrug resistance for cervical carcinoma, the positive expression of P-gp is one of the reasons for chemotherapy failure.
出处
《汕头大学医学院学报》
2006年第2期98-99,共2页
Journal of Shantou University Medical College