脂肪肝脂质过氧化与细胞因子TNF-α、IGF-1水平的临床观察

Clinical study of the relationship about fatty liver lipid peroxides with tumor necrosis factor α and insulin-likegrowth factorl.

探讨脂肪肝的脂质过氧化与细胞因子的相关性。选择64例脂肪肝患者,测定血清中丙二醛(m alond i-aldehyde,MDA)、超氧化物歧化酶(superoxide d ismutase,SOD)、肿瘤坏死因子α(tumor necrosis factor,αTNF-α)、胰岛素样生长因子1(insu lin-likegrowth factor 1,IGF-1)的水平,并选择56例非脂肪肝的健康人为正常对照。结果显示脂肪肝患者MDA和TNF-α水平升高,与正常组比均为(P<0.05);SOD和IGF-1水平下降,与正常组比分别为(P<0.05,P<0.01)。提示脂肪肝患者存在脂质过氧化,与TNF-α和IGF-1存在相关性。

To observe as study group the relationship about fatty liver lipid peroxides and cell factor. 64 fatty liver cases were selected, the level of MDA ,SOD ,TNF - α and IGF - 1 were tested. 56 healthy cases were as contral group. The results demonstrated that the level of MDA and TNF - α were higher, than that of control group （ P 〈 0. 05, respectively） ; while the 1 evel of SOD and IGF - 1 were lower, than that of control group （P 〈0. 05 ,P 〈0. 01 ,respectively）. The study shows that fatty liver exists lipid peroxides and was related to TNF - α and IGF - 1.