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DNA倍体分析在肺癌中的意义 被引量:1

DNA Ploidy Analysis in Lung Carcinoma
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摘要 目的:研究DNA倍体和增殖指数(proliferation index,PI)的检测在肺癌侵袭和转移中的意义。方法:流式细胞分析72例组织(包括57例肺癌组织和15例癌旁对照组织)的DNA倍体和PI。结果:流式细胞结果显示DNA倍体、PI在癌旁对照组织和肺癌组织之间都存在显著性差异(P<0.05)。57例肺癌组织的PI在TNM分期、组织分化、组织类型中均存在显著性差异(p<0.05),但和淋巴结转移无关,DNA倍体在淋巴结有无转移之间存在显著性差异(P<0.05)。结论:随着肿瘤异质性的发生和发展,DNA异倍体率的增加,肺癌患者发生淋巴结转移的可能性也大大增加,表明DNA异倍体率在肺癌侵袭和转移的发生中扮演了一个重要角色,但PI的增加和淋巴结转移无关。 Objective:To investigate DNA ploidy in lung carcinoma and to explore the mechanism of invasion and metastasis of lung carcinoma. Methyls.Flow cytometry DNA ploidy and proliferation index (PI) analysis were performed on the 72 cases, including 57 cases of lung carcinoma, 15 cases of adjacent noncancerous tissues. Results: Flow cytometry DNA ploidy and PI were significantly correlated with lung carcinoma and adjacent noncancerous tissues(P〈 0.05). PI was significantly correlated with TNM stage, tissue differation and tissue classification (P〈 0.05), but PI was no significantly correlated with LN metastasis, DNA ploidy were significantly correlated with LN metastasis (P〈 0.05)in 57 cases lung carcinoma. Conclusions: With tumor progression and development of heterogeneity, DNA aneuploid rate gradually increases, lymph node metastasis rate is also increase,suggesting that they play a crucial role in Lung carcinoma progression. But our findings show no correlation of PI and lymph nodemetastasis.
出处 《内蒙古医学杂志》 2006年第6期506-508,共3页 Inner Mongolia Medical Journal
关键词 肺癌 DNA倍体 增殖指数 Lung carcinoma DNA ploidy PI
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