摘要
目的:与偶测血压比较.观察动态血压与肾脏损害的关系,同时与常规检查肾功能方法作比较,观察高血压病不同时期的肾脏损害。方法:采用放射免疫法测定血、尿β_2-微球蛋白(β_2-MG),结合24小时动态血压监测,以21例正常血压者作对照,观察63例高血压患者肾脏功能变化。结果:24小时平均动脉压及日间平均动脉压负荷与血、尿β_2-MG明显相关(P<0.01),日间平均动脉压与之相关性最好(P<0.01),夜间平均动脉压和夜间平均动脉压负荷与之也有相关性(P<0.05),而与偶测血压则无相关(P>0.05)。动态血压监测昼夜节律消失者,肾功能损害明显。尿β_2-MG在轻型高血压时即已出现异常。结论:动态血压监测和尿β_2-MG能更好地反映血压与肾脏损害的关系,有利于早期肾脏损害的发现,以便尽早防治。
Objective: To observe the correlations between renal impairment and ABP or CBP. Methods: β_2-MG contents in blood and urine were determined by radioimmunoassay, ABP and CBP were measured in 63 hypertensives and 21 normotensives. Correlation analysis was performed between β_2-MG and the levels of CBP or 24-hour ABP. Results: Significant correlations were found between β_2-MG in blood or urine and ABP——nighttime mean arterial pressures (n-MAP),n-MAP load (n-MAPL), MAP, day-time MAPL (d-MAPL),(p<0.05 ,p<0.05 ,p<0.01,10<0.001, respectively). But, no correlations were found between β_2-MG in blood or urine and CBP. Subjects who lost day-time BP rhythm showed more obvious damage of renal function than those had normal BP rhythm. Even at early stage of hypertension, both blood and urine β_2-MG increased (p<0. 05,p<0.001 vs. normal controls, respectively) and these increases appeared ealier than blood creatinine (Cr). Conclusion: ABP and urine β_2-MG could reflect better the relationship between BP and renal damage than CBP and urine Cr.
出处
《中国循环杂志》
CSCD
1996年第6期329-332,共4页
Chinese Circulation Journal
关键词
高血压
动态血压
Β2-微球蛋白
尿液
Blood pressure
Ambulatory blood pressure monitoring
β_2-Microglobulin