IL-6及CRP在早期诊断新生儿败血症中的临床研究

Clinical and Lab Studies on the value of IL-6 and CRP in Early Diagnose of Neonatal Sepsis

目的探索新生儿败血症的早期诊断手段,评价白细胞介素6(IL-6)和C反应蛋白(CRP)在新生儿败血症早期诊中的临床价值。方法按败血症的诊断标准,23例新生儿败血症(确诊新生儿败血症病例9例,临床诊断新生儿败血症14例)作为研究组,35例无感染病例作为对照组;比较两者IL-6、CRP的差异。结果研究组的血清IL-6、CRP浓度分别为(68.5±24.1)ng/L、(23.2±7.8)mg/L,对照组的血清IL-6和CRP浓度分别为(35.8±11.4)ng/L、(8.6±3.1)mg/L,统计比较均有显著性差异;以对照组95%可信区间上限为切割值,IL-6和CRP的敏感性分别为87%、60.8%,特异性分别为82.9%、88.6%。结论IL-6、CRP可作为早期诊断新生儿败血症的指标,对制定治疗方案,改善预后具有重要的参考意义。

Objective To investigate the value oflnterleukin- 6 （IL-6） and C-reactive protein （CRP） on early diagnose of neonatal sepsis. Methods 58 newborns were divided into bacterial infection group （n=23） and non-infection group （n=35） according to the diagnostic criteria of bacterial infection .The infection group was further divided into bacteria-positive and negative groups. Serum IL-6 and CRP levels were measured in 23 newborns with sepsis and in 35 health infants. Comparisons were done between those patients and health control. Results Serum IL-6 and CRP levels in-group of neonatal septicemia was significantly higher than that of normal controls. It was identified that the IL-6 optimal cut-off point of diagnostic reference value was obtained with percentile mode should be 58.1ng/L or more with the sensitivity of 81%and the specificity of 83%, and the CRP with the sensitivity of 60.8% and the specificity of 88.6%. Conclusion Serum IL-6 and CRP might be looked as an early indicator for neonatal sepsis and have significance of making therapeutic schemes and improving prognosis.