肺炎并心力衰竭婴幼儿红细胞内钙、血清心肌肌钙蛋白I变化及其与心功能的关系

Changes of Intraerythrocytic Calcium,Serum Cardiac Troponin I and Their Relationships with Heart Function in Infants with Pneumonia Complicated with Heart Failure

目的研究婴幼儿肺炎并不同程度心力衰竭(心衰)时红细胞内钙质量浓度变化、血清心肌肌钙蛋白I(cTnI)水平变化及其与心功能的关系。方法选择肺炎及肺炎并心衰患儿133例作为试验组,健康婴幼儿30例作为对照组,均抽血测定红细胞内钙水平、血清cTnI。应用多普勒超声心动图测定其左室射血分数(EF)、左室短轴缩短率(FS)及二尖瓣E峰A峰比值(E/A)。结果两组红细胞内钙水平、血清cTnI、EF、FS、E/A值有明显差异,心衰程度越重,红细胞内钙水平、血清cTnI越高,EF、FS、E/A越低,红细胞内钙水平、cTnI与EF、FS、E/A呈负相关。结论心肌细胞内钙离子、cTnI参与心衰的发生、发展,其变化可间接反映心脏收缩、舒张功能的改变。

Objective To evaluate the relationship of intraerythrocytic calcium（Ca^2＋ ）,seruna cardiac troponin I（cTnI） and contractile and diastolic dysfunction in infants with pneumonia complicated with heart failure（HF）, and discuss the role of Ca^2＋ and cTnI. Methds One hundred and thirty- three infants with pneumonia complicated with HF and 30 healthy children were studied. Intraerythrocytic calcium, serum cTnI and ejection fraction （EF）, fractional shortening （FS） and E/A were measured by color Doppler ultrasoundraphy. Results Intraerythroeytic calcium, serum cTnI and EF, FS and E/A in two groups had difference. With the disease deteriorating, the values of Ca^2＋ and cTnI increased, and EF, FS,E/A decreased gradually. There were negative relations between Ca^2＋ ,cTnI and EF,FS,E/A.Conclusions Ca^2＋ ,cTnI are concemed with the development of HF. In clinical experiments,the contractile function and diastolic function of heart can be judged by the levels of intraerythrocytic calcium and serum cTnI.