逍遥散和丹栀逍遥散抗焦虑作用的实验研究

Experimental Study on Antianxietic Action of Xiaoyao San and Dan Zhi Xiaoyao San

【目的】探讨逍遥散、丹栀逍遥散的抗焦虑作用。【方法】Wistar大鼠随机分为5组:模型对照组、丹栀逍遥散高剂量组(剂量为14.4 g/kg)、丹栀逍遥散低剂量组(剂量为7.2 g/kg)、逍遥散高剂量组(剂量为21.06 g/kg)、逍遥散低剂量组(剂量为10.53 g/kg),采用群居接触模型及旷场实验模型观察逍遥散和丹栀逍遥散对模型大鼠的抗焦虑作用。模型组灌服生理盐水,其他组灌服相应剂量的药物,连续14 d后,由2名观察者观察大鼠在5 min内的活动情况并记录结果,取其平均值。【结果】丹栀逍遥散高、低剂量组均能增加群居接触时间,增加大鼠竖起或修饰次数,逍遥散低剂量组可增加大鼠竖起或修饰次数(P<0.05或P<0.01)。【结论】逍遥散和丹栀逍遥散均具有一定的抗焦虑作用,以丹栀逍遥散作用更佳。

[ Objective] To investigate the antianxietic action of Xiaoyao San （XS） and Dan Zhi Xiaoyao San （DZXS）. [Methods] Wistar rats were randomized into 5 groups： model control group, high- and low-dose DZXS groups （ 14.4 g/kg and 7.2 g/kg respectively）, and high- and low-dose XS groups （21.06 g/kg and 10.53g/kg respectively）. Social interaction test and open-field test were carried out to observe the antianxietic action of XS and DZXS. Except that the model group was given normal saline, the rats in other groups were given the corresponding drugs according to the experimental design for 14 successive days. After treatment, the activities within 5 min were monitored by two observers and then the mean value were calculated. [Results] High- and low-dose DZXS prolonged rats social interaction time and increased the times of body erection and dressing their hair, and low-dose XS also increased the times of body erection and dressing their hair （ P 〈0.05 or P 〈0.01 as compared with the model group）. [Conclusion] Both XS and DZXS have the antianxietic action, in particular DZXS.