期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

G-CSF对洛伐他汀诱导的K562细胞内酸碱度及凋亡的影响 被引量：1

原文传递
导出
摘要 重组人粒细胞集落刺激因子（rhG—CSF）广泛用于防治放化疗后的粒细胞减少，但G—CSF可以抑制肿瘤细胞的凋亡。已有研究报道，细胞内碱性化，即细胞内酸碱度（pHi）值升高可以使DNA合成增加，细胞增殖，同时抑制细胞凋亡。我们对G—CSF在洛伐他汀（LOV）诱导K562细胞凋亡作用中的影响及其机制进行了初步探讨。
作者 何秉燕 邓长生 邹典定 刘湘芬 易有荣
机构地区 武汉大学中南医院儿科 武汉大学中南医院消化内科 武汉大学医学院生物医学结构中心
出处 《中华血液学杂志》 CAS CSCD 北大核心 2006年第7期479-480,共2页 Chinese Journal of Hematology
关键词 细胞内酸碱度 K562细胞 细胞凋亡 洛伐他汀 CSF 重组人粒细胞集落刺激因子 抑制肿瘤细胞 粒细胞减少 DNA合成 放化疗后
分类号 R96 [医药卫生—药理学]
  • 相关文献

参考文献7

  • 1何秉燕,张渝侯,邹典定,陈冬珍,许家琪.rhG-CSF抑制脐血CD_3AK细胞和其培养上清液诱导K_(562)细胞凋亡的研究[J].中华儿科杂志,2000,38(4):220-222. 被引量：3
  • 2Lee CH,Gragoe EJ,Edwards AM.Control of hepatocyte DNA synthesis by intracellular pH and its role in the action of tumor promoters.J Cell Physiol,2003,195:61-69.
  • 3Wang IK,Lin-Shiau SY,Lin JK.Supression of invasion and MMP-9expression in NIH 3T3 and v-H-Ras 3T3 fibroblasts by lovastatin through inhibition of ras isoprenylation.Oncology,2000,59:245-254.
  • 4Agarwal B,Halmos B,Feoktistov AS,et al.Mechanism of lovastatin-induced apoptosis in intestinal epithelial cells.Carcinogenesis,2002,23:521-528.
  • 5韦娜,糜漫天,张乾勇,杨志祥.洛伐他汀对MCF-7细胞核转录因子和细胞周期调控蛋白表达的影响[J].中华肿瘤杂志,2003,25(4):332-334. 被引量：12
  • 6Tanaka K,Nibu K.Laryngeal squamous cell carcinoma with ectopic production of granulocyte colony-stimulating factor and parathyroid hormone-related protein.Int J Clin Oncol,2005,10:195-197.
  • 7Rich IN,Worthington-While D,Garden OA,et al.Apoptosis of leukemic cells accompanies reduction in intracellular pH after targeted inhibition of the Na ^+/H^ + exchanger.Blood,2000,95:1427-1434.

二级参考文献16

  • 1赵桂芝,陈华,林珠,吴军正,柯杰.恒磁场对人牙周膜成纤维细胞DNA代谢的影响[J].中华口腔医学杂志,1994,29(2):75-78. 被引量：13
  • 2Wang IK, Lin-Shiau SY, Lin JK. Suppression of invasion and MMP-9 expression in NIH 3T3 and v-H-Ras 3T3 fibroblasts by lovastatin through inhibition of ras isoprenylation. Ontology, 2000, 59: 245-254.
  • 3Agarwal B, Halmos B, Feoktistov AS, et al. Mechanism of lovastatin-induced apoptosis in intestinal epithelial cells. Carcinogenesis, 2002,23: 521-528.
  • 4Shibata A, Nagaya T, Imai T, et al. Inhibition of NF-kappaB activity decreases the VEGF mRNA expression in MDA-MB-231 breast cancer cells. Breast Cancer Res Treat, 2002, 73: 237-243.
  • 5Birbach A, Gold P, Binder BR, et al. Signaling molecules of the NF-kappa B pathway shuttle constitutively between cytoplasm and nucleus. J Biol Chem, 2002, 277: 10842-10851.
  • 6Gnad R, Kaina B, Fritz G. Rho GTPases are involved in the regulation of NF-kappaB by genotoxic stress. Exp Cell Res, 2001, 264: 244-249.
  • 7Joyce D, Albanese C, Steer J, et al. NF-kappaB and cell-cycle regulation: the cyclin connection. Cytokine Growth Factor Rev, 2001,121 : 73-90.
  • 8Namazie A, Alavi S, Olopade OI, et al. Cyclin D1 amplification and p16 (MTS1/CDK4I) deletion correlate with poor prognosis in head and neck tumors. Laryngoscope, 2002, 112: 472-481.
  • 9Li J, Tsai MD. Novel insights into the INK4-CDK4/6-Rb pathway:counter action of gankyrin against INK4 proteins regulates the CDK4-mediated phosphorylation of Rb. Biochemistry, 2002, 41 : 3977-3983.
  • 10Martinez BJ, Ferroel A J, Suarez Y, et al. Dose-dependent effects of lovastatin on cell cycle progression: distinct requirement of cholesterol and non-sterol mevalonate derivatives. Biochim Biophys Acta, 2001,1532: 185-194.

共引文献13

同被引文献10

  • 1康春生,浦佩玉,李捷,于士柱,王虎,江荣才,董伦,王广秀.人脑胶质瘤MMP2、MMP9和Ki-67的表达及其相关性的探讨[J].中国肿瘤临床,2004,31(14):820-823. 被引量：4
  • 2Kleihues P, Louis DN, Scheithauer BW, et al. The WHO classification of tumors of the nervous system [J].J Neuropathol Exp Neurol, 2002, 61 (3): 215-225
  • 3Saadoun S, Papadopoulos MC, Krishna S. Water transport becomes uncoupled from K^+ siphoning in brain contusion, bacterial meningitis, and brain tumours [J].J Clin Pathol, 2003, 56(12):972-975
  • 4世界卫生组织对脑肿瘤的修正分类(1993)．见：黄文清,主编．神经肿瘤病理学[M]，第二版．北京：军事医学科学出版社，2001．10
  • 5Butt AM, Kalsi A. Inwardly rectifying potassium channels (Kit) in central nervous system glia: a special role for Kir4.1 in glial functions[J].J Cell Mol Med, 2006, 10(1): 33-44
  • 6Benfenati V, Caprini M, Nobile M, et al. Guanosine promotes the up-regulation of inward rectifier potassium current mediated by Kir4.1 in cultured rat cortical astrocytes[J].J Neurochem, 2006, 98(2): 430-445
  • 7Warth A, Mittelbronn M, Wolburg H. Redistribution of the water channel .protein aquaporin-4 and the K^+ channel protein Kir4.1 differs in low- and high-grade human brain tumors [J]. Acta Neuropathol(Berl), 2005, 109(4): 418-426
  • 8Amiry-Moghaddam M, Williamson A, Palomba M, et al. Delayed K^+ clearance associated with aquaporin-4 mislocalization: phenotypic defects in brains of alpha-syntrophin-null mice[J]. proc Natl Acad Sci U S A, 2003, 100(23): 13615-13620
  • 9Jablonski EM, Webb AN, McConnell NA, et al. Plasma membrane aquaporin activity can affect the rate of apoptosis but is inhibited after apoptotic volume decrease [J]. Am J Physiol Cell Physiol, 2004, 286(4): C975-C985
  • 10杜肖娜,王川,贾庆忠,张海林.细胞内pH对胆碱能受体介导的Kir3.1/3.4电流的调节[J].中国药理学通报,2004,20(1):53-58. 被引量：2

引证文献1

中华血液学杂志
2006年 第7期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部