摘要
目的探讨芪参降脂饮对实验性动脉粥样硬化(AS)大鼠的血管内皮功能及胰岛素敏感性(IS)的影响。方法24只大鼠随机分为正常对照组、高脂对照组、芪参降脂饮组,每组各8只,分别予以普通饲料和高脂饲料,芪参降脂饮组同时灌服芪参降脂饮。6 wk后分别测血脂谱、血FPG、FINS、ET、6-k-PGF1a、TXB2并计算ISI、TXB2/6-k-PGF1a。结果芪参降脂饮组大鼠TC、LDL-C、ET、TXB2、TXB2/6-k-PGF1a、FPG、FINS显著低于高脂对照组,而HDL-C、6-k-PGF1aI、SI明显升高(P<0.01)。结论芪参降脂饮可以改善血管内皮功能及增强IS进而起到抗AS的作用。
AIM To study the effects of Qishenjiangzhiyin(QSJZY) on vascular endotheial function and insulin sensitivity(IS) with experimental atherosclerosis(AS)rats induced by high fat diet. METHODS Twenty-four rats were randomized into 3 groups. One group served as normal control group, the second group was fed with high-fat diet and served as atherosclerosis model group. The third group was fed with high-fat diet in junction with QSJZY. Serum lipids, FPG, FINS, ET, 6-k-PGF1a, TXB2 were measured and ISI and TXB2/6-k-PGF1a were calculated after 6 wk after experiment. RESULTS In treatment group, TC, LDL-C, ET, TXB2, TXB2/6-k-PGF1a, FPG and FINS were significantly lower and HDL-C,6-k-PGF1a and ISI were significantly higher than those in high-fat group( P 〈 0.01 ). CONCLUSION QSJZY can improve vascular endotheial function and can enhance IS, which might be the mechanisms of QSJZY's antiatherosclerosis action.
出处
《中国临床药学杂志》
CAS
2006年第4期231-233,共3页
Chinese Journal of Clinical Pharmacy
基金
辽宁省教育厅科学研究计划资助(计划编号202203250)